The Cannabinoids and their effect on the human body

There is great evidence about the medical benefits for chronic pain, but for many other indications, such as pruritus, there is much less data available. However, the scientific evidence for a specific indication does not reflect the actual therapeutic potential of a disease.

Clinical studies with cannabinoids or whole plant preparations (smoked cannabis, cannabis extract) have often been inspired by positive anecdotal experiences of patients using cannabis products. Analgesia was discovered this way.


Components of the cannabis plant

The main components of the Cannabis plant are the cannabinoids. There are more than 85 known cannabinoids in the Cannabis plant. Cannabinoids are similar in structure but have drastically different effects.

The three main cannabinoids, THC (delta 9 tetrahydrocannabinol), CBD (cannabidiol) and CBN (cannabinol) have been the focus of many studies and are often referred to as the “cannabinoids”:

  • THC is the main psychoactive cannabinoid.
  • CBD is the main non-psychoactive cannabinoid.
  • CBN is the molecule of degradation of THC, so it retains some of its psychoactivity, but is mainly used as a sedative.




Is responsible for most of the psychoactive effects of marijuana. THC affects memory, pleasure, movements, thinking, concentration, coordination and the sensory and temporal perception of a person. The THC is responsible for “being placed” after smoking marijuana and, therefore, its production and use are strictly regulated. Some short-term effects of consuming THC are:

  • Euphoria
  • Relaxation
  • Sedation
  • Pain relief
  • Deterioration of memory
  • Energy
  • Hungry
  • Drowsiness
  • Increase of cardiac frequency
  • Dry mouth
  • Red eyes
  • Laugh
  • Dizziness
  • Anxiety / paranoia

THC has many medical benefits. There are many occasions in which THC is beneficial: Post Traumatic Stress Disorder (PTSD), neuropathic and chronic pain, insomnia, nausea, inflammation, arthritis, migraines, cancer, Crohn’s disease, fibromyalgia, Alzheimer’s disease, multiple sclerosis, glaucoma, Attention Deficit Disorder (ADHD), sleep apnea, or loss of appetite.

There is little evidence to support theories about the long-term effects of THC. Some of the possible effects after prolonged long-term THC consumption are anatomical changes in the brain, decrease in verbal cognitive function and reduction of body tolerance of THC.



It is a cannabinoid of the cannabis plant without psychotropic effect. It is the second most abundant compound in hemp. The importance of CBD is that it is not psychoactive, addictive or toxic.

Comparing THC and CBD, there are countless studies on THC, compared to CBD. THC activates the body’s endocannabinoid receptors (CB receptors). The mechanisms of the CBD are still being elucidated (Pertwee, 2006).

Several preclinical studies show that CBD is:

  • antioxidant.
  • reduces the pain.
  • reduces the inflammation.


Studies on CBD

CBD is generally found in higher concentrations in hemp than in marijuana. CBD has been consumed by humans for thousands of years as a component of the extracts and formulations of hemp and cannabis.

Interest in the CBD has increased dramatically in recent years due to its properties: it is not psychoactive, it is not addictive and it is not toxic.

It can have a therapeutic value in a large number of diseases, including inflammatory diseases, , and does not cause significant side effects (Grotenhermen et al., 2016).

Nowadays, preclinical and clinical studies are increasing showing that CBD and other cannabinoids are a natural complement to human health and are safe and non-toxic.

CBD seems to reduce the negative side effects of THC such as paranoia / anxiety. The latest research shows that CBD has a better therapeutic profile in general than THC (Russo, 2011).


In vivo / in vitro studies of the CBD

Based on multiple in vivo and in vitro reports on different doses of CBD administration, it was found that CBD is extremely safe and non-toxic: “Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes in intake. of food, does not induce catalepsy, does not affect the physiological parameters (heart rate, blood pressure and body temperature), does not affect the gastrointestinal transit and does not alter the psychomotor or psychological functions. In addition, the chronic use and high doses of up to 1,500 mg / CBD days are reportedly well tolerated in humans.” (Bergamaschi, et al, 2011.)

The only interesting effect observed is that CBD has a slight metabolic influence on cytochrome P450 (liver enzymes that metabolize toxins, drugs, etc.) at high doses. If the dose of cannabidiol is low enough, it will not have a noticeable effect on CYP450 activity. Clinical trials using the sublingual spray saturated with CBD from GW Pharmaceutical found no interactions with CYP450 enzymes when approximately 40 mg of CBD was administered).


Efficiency of the CBD. Applications

In recent years, CBD has proven effective in many areas, outlining pain and inflammation.

The US government has a patent on cannabinoids as antioxidants and neuroprotectors: patent US6630507:

The CBD, thanks to its lack of toxicity and being so safe, makes it an ideal natural analgesic product. Cannabinoids as analgesics have been well tolerated in clinical trials. Side effects are minimal and long-term use is well tolerated.

CBD has a similar effect to THC without the psychoactivity and has been found to interact with other receptors of the cannabinoid system decreasing the cycle of autoimmune inflammation.

In recent studies (February 2016) a report was published in which they reviewed 32 clinical studies from 2010 to 2014, conducted with cannabinoids ( The researchers found that based on clinical results, cannabinoids present an interesting therapeutic potential mainly as analgesics in chronic neuropathic pain and spasticity in multiple sclerosis. They founded other indications for CBD that also seemed promising for therapeutic purposes.

Applying CBD daily is an efficient way to stimulate your ECS and increase your health and vitality.